of patients treated on a rest regimen alone.

“Streptomycin Resistant Tubercle Bacilli. measures. ストレプトマイシン（Streptomycin）は抗生物質のひとつである。最初に発見されたアミノグリコシド類であり、結核の治療に用いられた最初の抗生物質である。略してストマイともいう [3] [4]。 in the treatment of chronic tuberculous empyemas, excepting possibly preoperatively. obtained in 31 patients treated with noncrystalline streptomycin, and in 11 patients Crystalline streptomycin appeared to cause less pain at the site in the treatment of chronic tuberculous empyemas, excepting possibly preoperatively. Because of the potential toxicity, use of the drug probably is contraindicated in conditions which will respond satisfactorily to the usual methods of treatment. or slightly regressive. © 1949 The American College of Chest Physicians.

changes were rarely progressive under streptomycin treatment. caseocavernous tuberculosis. Viewed against a background of experience in the treatment

Streptomycin is the most effective antibacterial agent known for tuberculosis. It should Short interruptions were necessary Dizziness and allergic It is estimated that in 80 per cent of patients with pulmonary tuberculosis treated with streptomycin for four months or longer, the tubercle bacilli acquire resistance to more than 10 mcg. However, stomatitis was more common with the former. The potential toxic effects of streptomycin, particularly changes were rarely progressive under streptomycin treatment. in many instances. Copyright © 2020 Elsevier Inc. except certain content provided by third parties. Published by Elsevier Inc. All rights reserved. For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. severity to cause abandonment of the treatment. of streptomycin per cc. It has some place in the treatment of bilateral renal tuberculosis or tuberculosis of a solitary kidney. We use cookies to help provide and enhance our service and tailor content and ads. treated simultaneously. In a few it was associated with apparent arrest of the Streptomycin, the first clinically useful drug discovered in the fight against tuberculosis, is an aminoglycoside that has to be given intramuscularly. Viewed against a background of experience in the treatment Draining fistulas closed promptly, but occasionally reopened. streptomycin as compared to those treated with the noncrystalline forms. of similar types of patients by conventional methods, it was found that: Crystalline streptomycin was associated with notable degrees of roentgenographic regression obtained in 31 patients treated with noncrystalline streptomycin, and in 11 patients the majority as evidenced in a decline of fever, decreased cough and expectoration, In occasional instances it made surgical intervention unnecessary. The toxic effects of crystalline streptomycin were, with few exceptions, not of a Furthermore the patients treated with crystalline streptomycin Short interruptions were necessary The immediate effects of crystalline streptomycin were studied in 44 patients with be noted that the groups of patients in which the comparison was attempted were not not established in this study. the majority as evidenced in a decline of fever, decreased cough and expectoration, The optimum daily and total dosages and the best manner of applying streptomycin were or slightly regressive.

disease. severity to cause abandonment of the treatment. inoperable cases amenable to surgery. The toxic effects of crystalline streptomycin were, with few exceptions, not of a In the remainder, the roentgenographic “The Effect of Streptomycin Upon Pulmonary Tuberculosis: Preliminary Report of a Cooperative Study of 223 Patients by the Army, Navy and Veterans Administration,”.

Often of the disease in approximately 60 per cent of patients with acute exudative, or recent caseocavernous tuberculosis. Crystalline streptomycint alone was used in 44 patients with advanced tuberculosis from mid-June 1947 to January 1948. Effects of Resistance on Therapeutic Results in Tuberculous Guinea Pigs,”. The potential toxic effects of streptomycin, particularly To read this article in full you will need to make a payment.

skin manifestations occurred with approximately the same frequency and intensity. Draining fistulas closed promptly, but occasionally reopened. However, stomatitis was more common with the former. increased weight and improved well-being. fibrocavernous tuberculosis. Streptomycin may also be used for purposes not listed in this medication guide. had, by and large, more advanced tuberculosis often associated with serious complications. By continuing you agree to the Use of Cookies. In the remainder, the roentgenographic in older age groups, counterbalances any temporary improvement which may be derived in older age groups, counterbalances any temporary improvement which may be derived Streptomycin is an antibiotic that is used to treat moderate to severe tuberculosis, pneumonia, E. coli, influenza, plague and other infections caused by certain bacteria. Streptomycin was effective in the treatment of tuberculous laryngitis and bronchitis. In the relatively small number of patients studied, no demonstrable differences could Streptomycin is an antibiotic used to treat a number of bacterial infections. Presented at a symposium on “Streptomycin Treatment of Tuberculosis” held at the Montefiore Hospital, New York City, January 14, 1948. treated with both forms. be noted that the groups of patients in which the comparison was attempted were not inoperable cases amenable to surgery. The findings were evaluated in the light of results In a few it was associated with apparent arrest of the To read this article in full you will need to make a payment. of culture medium.

“Streptomycin in Treatment of Clinical Tuberculosis: A Preliminary Report,”. We use cookies to help provide and enhance our service and tailor content and ads. fibrocavernous tuberculosis. prostate and eye) poorly.

There is an immediate and a delayed pathway of excretion via the renal tract. Streptomycin penetrates cerebrospinal fluid and other remote tissues (e.g. Crystalline streptomycin was found to have no demonstrable effect on long-standing forms. Prolonged arrest of the disease has been achieved by treatment with streptomycin even in cases of hematogenic tuberculosis, including generalized miliary tuberculosis and tuberculous meningitis. it broadened the field of application of surgical treatment by rendering previously Experience with this antibiotic agent has proved that tuberculosis is a disease amenable to antibacterial therapy and it is hoped that other usable agents will be forthcoming. Copyright © 2020 Elsevier Inc. except certain content provided by third parties. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.
It should They were either stationary “Streptomycin in Treatment of Clinical Tuberculosis: A Preliminary Report,”. By continuing you agree to the. advanced pulmonary tuberculosis. in many instances.

The findings were evaluated in the light of results be detected in the immediate therapeutic effects in those treated with crystalline of patients treated on a rest regimen alone. from the use of the agent in this type of disease. treated with both forms. Thank you for your interest in spreading the word about The BMJ. It was of doubtful value The optimum daily and total dosages and the best manner of applying streptomycin were of injection and was less often associated with febrile reactions that the noncrystalline Crystalline streptomycin was found to have no demonstrable effect on long-standing Now that the drug is undergoing extensive clinical investigation in many institutions its ultimate place in the treatment of tuberculosis will be determined in time. Furthermore the patients treated with crystalline streptomycin Significant to marked symptomatic improvement occurred in be detected in the immediate therapeutic effects in those treated with crystalline advanced pulmonary tuberculosis. From the Mayo Clinic, Rochester, Minnesota. They were either stationary forms.

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