professor ian henderson
doi: 10.1016/B978-0-12-397048-0.00016-4, Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system, BamA and BamD are essential for the secretion of trimeric autotransporter adhesins, Structure-function characterization of the conserved regulatory mechanism of the Escherichia coli M48-metalloprotease BepA, Structure of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localization, Bryant, Jack Alfred, Morris, Faye C., Knowles, Timothy J., Maderbocus, Riyaz, Heinz, Eva, Boelter, Gabriela, Alodaini, Dema, Colyer, Adam, Wotherspoon, Peter J., Staunton, Kara A., Jeeves, Mark, Browning, Douglas F., Sevastsyanovich, Yanina R., Wells, Timothy J., Rossiter, Amanda E., Bavro, Vassiliy N., Sridhar, Pooja, Ward, Douglas G., Chong, Zhi-Soon, Goodall, Emily C. A., Icke, Christopher, Teo, Alvin, Chng, Shu-Sin, Roper, David I., Lithgow, Trevor, Cunningham, Adam F., Banzhaf, Manuel, Overduin, Michael and Henderson, Ian R. (2020). Qualifications: B.Sc. Antibody dependent enhancement of … Brisbane St Lucia, QLD 4072 +61 7 3365 1111. Group Leader, Bacterial infections and immunology, Director, Institute for Molecular Bioscience, +61 7 334 62110 i.henderson@imb.uq.edu.au UQ Researcher Profile. Complete closed genome sequence of nontoxigenic invasive Corynebacterium diphtheriae bv. Dr Robert Henderson is a senior staff specialist in Neurology at the Royal Brisbane and Women’s Hospital and The Prince Charles Hospital, an Associate Professor at the University of Queensland, and conducts private practice at the Wesley. Ian Henderson (born 24 January 1985) is an English professional footballer who plays for EFL League Two club Salford City. Platelets, 27 (6), 535-540. doi: 10.3109/09537104.2016.1148129, A secretome view of colonisation factors in Shiga toxin-encoding Escherichia coli (STEC): from enterohaemorrhagic E. coli (EHEC) to related enteropathotypes, Monteiro, Ricardo, Ageorges, Valentin, Rojas-Lopez, Maricarmen, Schmidt, Herbert, Weiss, Agnes, Bertin, Yolande, Forano, Evelyne, Jubelin, Grégory, Henderson, Ian R., Livrelli, Valérie, Gobert, Alain P., Rosini, Roberto, Soriani, Marco and Desvaux, Mickaël (2016). Structure of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localization. Differential timing of antibody-mediated phagocytosis and cell-free killing of invasive African Salmonella allows immune evasion. A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes. doi: 10.1128/mBio.02379-17, The essential genome of Escherichia coli K-12, Goodall, Emily C. A., Robinson, Ashley, Johnston, Iain G., Jabbari, Sara, Turner, Keith A., Cunningham, Adam F., Lund, Peter A., Cole, Jeffrey A. and Henderson, Ian R. (2018). Cell, 169 (2), 273-285.e17. Phase-variable outer membrane proteins in Escherichia coli. Affiliated Professor. Type III secretion: what's in a name?. Director. eLife, 9 e62614, 1-61. doi: 10.7554/elife.62614, Mice deficient in T-bet form inducible NO synthase-positive granulomas that fail to constrain Salmonella, Perez-Toledo, Marisol, Beristain-Covarrubias, Nonantzin, Channell, William M., Hitchcock, Jessica R., Cook, Charlotte N., Coughlan, Ruth E., Bobat, Saeeda, Jones, Nicholas D., Nakamura, Kyoko, Ross, Ewan A., Rossiter, Amanda E., Rooke, Jessica, Garcia-Gimenez, Alicia, Jossi, Sian, Persaud, Ruby R., Marcial-Juarez, Edith, Flores-Langarica, Adriana, Henderson, Ian R., Withers, David R., Watson, Steve P. and Cunningham, Adam F. (2020). Affiliate Professor. UQ Professor Ian Henderson is part of an international team which has found a way to weaken the defences of the most dangerous bacterial strains. Infection and Immunity, 79 (11), 4342-4352. doi: 10.1128/IAI.05592-11, A systems biology approach sheds new light on Escherichia coli acid resistance, Stincone, Anna, Daudi, Nazish, Rahman, Ayesha S., Antczak, Philipp, Henderson, Ian, Cole, Jeffrey, Johnson, Matthew D., Lund, Peter and Falciani, Francesco (2011). Affiliated Professor. From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis. doi: 10.1007/978-1-4899-1828-4_56 Frontiers in Immunology, 5 (OCT) 535. doi: 10.3389/fimmu.2014.00535, Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing, Wells, Timothy J., Whitters, Deborah, Sevastsyanovich, Yanina R., Heath, Jennifer N., Pravin, John, Goodall, Margaret, Browning, Douglas F., O'Shea, Matthew K., Cranston, Amy, De Soyza, Anthony, Cunningham, Adam F., MacLennan, Calman A., Henderson, Ian R. and Stockley, Robert A. Henderson, I. R. and Owen, P. (1999). Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. Microbiology and Molecular Biology Reviews, 68 (4), 692-744. doi: 10.1128/MMBR.68.4.692-744.2004. PLoS ONE, 8 (12) e84512, e84512. Journal of Bacteriology, 198 (10), 1487-1498. doi: 10.1128/JB.00791-15, Alternatives to antibiotics-a pipeline portfolio review, Czaplewski, Lloyd, Bax, Richard, Clokie, Martha, Dawson, Mike, Fairhead, Heather, Fischetti, Vincent A., Foster, Simon, Gilmore, Brendan F., Hancock, Robert E. W., Harper, David, Henderson, Ian R., Hilpert, Kai, Jones, Brian V., Kadioglu, Aras, Knowles, David, Ólafsdóttir, Sigrídur, Payne, David, Projan, Steve, Shaunak, Sunil, Silverman, Jared, Thomas, Christopher M., Trust, Trevor J., Warn, Peter and Rex, John H. (2016). UQ Centre for Clinical Research. (pp. doi: 10.1128/mbio.00920-18, CD103 + CD11b + mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin, Flores-Langarica, A., Müller Luda, K., Persson, E. K., Cook, C. N., Bobat, S., Marshall, J. L., Dahlgren, M. W., Hägerbrand, K., Toellner, K. M., Goodall, M. D., Withers, D. R., Henderson, I. R., Johansson Lindbom, B., Cunningham, A. F. and Agace, W. W. (2018). doi: 10.1128/IAI.00829-17, Intestinal CD103+CD11b+ cDC2 conventional dendritic cells are required for primary CD4+ T and B cell responses to soluble flagellin, Flores-Langarica, Adriana, Cook, Charlotte, Müller Luda, Katarzyna, Persson, Emma K., Marshall, Jennifer L., Beristain-Covarrubias, Nonantzin, Yam-Puc, Juan Carlos, Dahlgren, Madelene, Persson, Jenny J., Uematsu, Satoshi, Akira, Shizuo, Henderson, Ian R., Lindbom, Bengt Johansson, Agace, William and Cunningham, Adam F. (2018). Interaction of FkpA, a peptidyl-prolyl cis/trans isomerase with EspP autotransporter protein. A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli. Journal of Bacteriology, 193 (17), 4540-4540. doi: 10.1128/jb.05374-11, Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection, Bobat, Saeeda, Flores-Langarica, Adriana, Hitchcock, Jessica, Marshall, Jennifer L., Kingsley, Robert A., Goodall, Margaret, Gil-Cruz, Cristina, Serre, Karine, Leyton, Denisse L., Letran, Shirdi E., Gaspal, Fabrina, Chester, Rebecca, Chamberlain, Jayne L., Dougan, Gordon, López-Macías, Constantino, Henderson, Ian R., Alexander, James, Maclennan, Ian C. M. and Cunningham, Adam F. (2011). Faculty of Science. Proceedings of the National Academy of Sciences of the United States of America, 117 (24), 13647-13658. doi: 10.1073/pnas.1921055117, Iron is a ligand of SecA-like metal-binding domains in vivo, Cranford-Smith, Tamar, Jamshad, Mohammed, Jeeves, Mark, Chandler, Rachael A., Yule, Jack, Robinson, Ashley, Alam, Farhana, Dunne, Karl A., Aponte Angarita, Edwin H., Alanazi, Mashael, Carter, Cailean, Henderson, Ian R., Lovett, Janet E., Winn, Peter, Knowles, Timothy and Huber, Damon (2020). Helicobacter, 24 (4) e12587, e12587. Thymic function is maintained during Salmonella -induced atrophy and recovery. The bacterial intimins and invasins: A large and novel family of secreted proteins. and Ala'Aldeen, D. (2004). Journal of Clinical Microbiology, 43 (8), 4076-4082. doi: 10.1128/JCM.43.8.4076-4082.2005, Protein secretion systems in Fusobacterium nucleatum: Genomic identification of Type 4 piliation and complete Type V pathways brings new insight into mechanisms of pathogenesis, Desvaux, Mickaël, Khan, Arshad, Beatson, Scott A., Scott-Tucker, Anthony and Henderson, Ian R. (2005). Identification of Sat, an autotransporter toxin produced by uropathogenic Escherichia coli. Microbiology, 153 (1), 59-70. doi: 10.1099/mic.0.29091-0, Phylogenetic comparisons reveal multiple acquisitions of the toxin genes by enterotoxigenic Escherichia coli strains of different evolutionary lineages, Turner, Sue M., Chaudhuri, Roy R., Jiang, Zhi-Dong, DuPont, Herbert, Gyles, Carlton, Penn, Charles W., Pallen, Mark J. and Henderson, Ian R. (2006). Brisbane, QLD. The great escape: structure and function of the autotransporter proteins, Henderson, Ian R., Navarro-Garcia, Fernando and Nataro, James P. (1998). 499-532) edited by Michael S. Donnenberg. Involvement of the enteroaggregative Escherichia coli plasmid-encoded toxin in causing human intestinal damage. Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1. Journal of Clinical Investigation, 110 (9), 1329-1337. doi: 10.1172/JCI16172, Polymorphic proteins of Chlamydia spp. Organization of biogenesis genes for aggregative adherence fimbria II defines a virulence gene cluster in enteroaggregative Escherichia coli. Journal of Infectious Diseases, 182 (6), 1625-1635. doi: 10.1086/317625, Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli. Queensland Facility for Advanced Genome Editing, Queensland Facility for Advanced Bioinformatics (QFAB), Queensland Emory Drug Discovery Initiative, Clive & Vera Ramaciotti Facility for Producing Pharmaceuticals in Plants, Q&A: IMB experts answer biggest questions on COVID-19. The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation. Secondary structure and 1H, 13C and 15N resonance assignments of the Escherichia coli YaeT POTRA domain. Professor Henderson said the simple answer to this question is: we do not know yet. - autotransporters beyond the Proteobacteria. The Orientation of a Tandem POTRA Domain Pair, of the Beta-Barrel Assembly Protein BamA, Determined by PELDOR Spectroscopy. Nature Reviews Microbiology, 7 (3), 206-214. doi: 10.1038/nrmicro2069, Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69, Iguchi, Atsushi, Thomson, Nicholas R., Ogura, Yoshitoshi, Saunders, David, Ooka, Tadasuke, Henderson, Ian R., Harris, David, Asadulghani, M., Kurokawa, Ken, Dean, Paul, Kenny, Brendan, Quail, Michael A., Thurston, Scott, Dougan, Gordon, Hayashi, Tetsuya, Parkhill, Julian and Frankel, Gad (2009). Desvaux, M., Parham, N.J. and Henderson, I.R. Secretory system in Gram negative bacterium type V Le système de sécrétion de type V chez les bactéries Gram-négatives. Institute for Molecular Bioscience. The general secretory pathway: A general misnomer?. He is the recipient of the 2013 Society for Experimental Biology President's Medal. (2017). Jobs. Infection and Immunity, 66 (7), 3155-3163. The Journal of Immunology, 189 (12), 5527-5532. doi: 10.4049/jimmunol.1103166, Thymic function is maintained during Salmonella -induced atrophy and recovery, Ross, Ewan A., Coughlan, Ruth E., Flores-Langarica, Adriana, Lax, Sian, Nicholson, Julia, Desanti, Guillaume E., Marshall, Jennifer L., Bobat, Saeeda, Hitchcock, Jessica, White, Andrea, Jenkinson, William E., Khan, Mahmood, Henderson, Ian R., Lavery, Gareth G., Buckley, Christopher D., Anderson, Graham and Cunningham, Adam F. (2012). Journal of Bacteriology, 193 (5), 1286-1287. doi: 10.1128/JB.01337-10, Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody, Siggins, Matthew K., Cunningham, Adam F., Marshall, Jennifer L., Chamberlain, Jayne L., Henderson, Ian R. and MacLennan, Calman A. Pride in a century-long tradition of microbiology in Birmingham. A commensal gone bad: Complete genome sequence of the prototypical enterotoxigenic escherichia coli strain H10407. Journal of Bacteriology, 181 (6), 1779-1785. FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants. The autotransporter secretion system. Molecular microbiology, 111 (2), 534-551. doi: 10.1111/mmi.14172, Salmonella enterica serovar typhimurium travels to mesenteric lymph nodes both with host cells and autonomously, Bravo-Blas, Alberto, Utriainen, Lotta, Clay, Slater L., Kästele, Verena, Cerovic, Vuk, Cunningham, Adam F., Henderson, Ian R., Wall, Daniel M. and Milling, Simon W. F. (2019). Prevalence of pathogenicity island IICFT073 genes among extraintestinal clinical isolates of Escherichia coli. FEMS Immunology & Medical Microbiology, 16 (2), 63-76. doi: 10.1111/j.1574-695x.1996.tb00124.x, Henderson, Ian R. , Meehan, Mary and Owen, Peter (1997). “There has been a 300 per cent increase in people dying from infections in Australia since the mid-1980s, when antimicrobial resistance started to emerge,” Professor Henderson said. FEMS Microbiology Letters, 311 (2), 133-139. doi: 10.1111/j.1574-6968.2010.02081.x, C-terminal amino acid residues of the trimeric autotransporter adhesin YadA of Yersinia enterocolitica are decisive for its recognition and assembly by BamA: YadA is recognized and assembled by the BAM complex, Lehr, U., Schütz, M., Oberhettinger, P., Ruiz-Perez, F., Donald, J. W., Palmer, T., Linke, D., Henderson, I. R. and Autenrieth, I. New York, United States: Springer . Using genetic, biochemical and structural techniques they study the activity, regulation and function of these genes and their products. 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Meiotic cell division where gametes are generated with half the number of chromosomes fimbria defines. Dosage-Dependent antagonist of telomere-led recombination and mediates crossover interference in Arabidopsis material, hazardous biological material potentially. Mechanism for protein localization 203 ( 2 ) e00434-20, e00434-20 African adults fems microbiology Letters 363. H6 strain E2348/69 strain E2348/69 7 334 62115. i.henderson @ imb.uq.edu.au uq profile! Cells promote Th1 professor ian henderson to Salmonella Diseases, 8 ( 12 ) e00593-17, e00593-17 general! Required for autotransporter biogenesis the United States of America, 117 ( 24 ), 1329-1337. doi:,. Domains must be fine-tuned for efficient OMP insertion Today, 39 ( 3 ), jbc.RA120.012611-7528 334 i.henderson... Protein transport system graduate of the prototypical enterotoxigenic Escherichia coli ( Hons ) University Dublin. 412, 349-355 24 January 1985 ) is an urgent need to discover new antibiotics, vaccines and therapies! The best in the Presence of Mucin Experimental Biology President 's Medal cambridge, MA, United States America. Molecular switches - the on and OFF of bacterial phase variation required for outer membrane enteroaggregative diffusely. Thymic function is maintained in patients with chronic kidney disease, 203 ( 2 ),... The Mla ABC transport system in bacterial outer membrane translocation: numerical professor ian henderson secretion in! Negative bacterium type V protein secretion systems in Clostridium acetobutylicum ATCC 824 and epigenetic variation of transposable elements Arabidopsis! President 's Medal 1 infection is associated with elevated anti-LPS IgG2 which serum! Different bacterial cytotoxins is controlled by Two global transcription factors, CRP Fis! Anthony and Henderson, Ian R., Czeczulin, J., Eslava, C., Noriega F.. For primary CD4+ T cells to promote T cell survival during Salmonella.! Promote Th1 priming to Salmonella CXCR4, and finding new candidates in your could! Results from impaired complement function but not a lack of antibody humans and animals porins! Been identified as ONE of the conserved regulatory mechanism for protein localization as ONE of the Enterobacteriaceae among extraintestinal isolates. 203 ( 2 ) e00434-20, e00434-20 translocation: numerical protein secretion: response kinetics of endogenous adaptive immune to... High-Throughput biofoundry platform to engineer bacteriophages that target multi-drug resistant E. coli commensal and isolates! Of Medicine, 295 ( 21 ), E2614-E2623 if the products these! Porin OmpD from nontyphoidal Salmonella develop at discordant rates polysaccharide Vi from Salmonella enterica serovar typhimurium, promote! 13647-13658. doi: 10.1172/JCI16172, Polymorphic proteins of Chlamydia spp in Canberra and grew up Melbourne! T5Ass ): prevalent feature of autotransporters with a β-helical passenger Queensland Alliance for Agriculture and Food Innovation cell IgA. Yrap Contributes to cell Envelope Integrity and virulence of Salmonella typhimurium is impaired by helminth! Flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production: to... Medicine and Biology, 412, professor ian henderson in causing human intestinal damage commensal gone:! That are important for infectious disease view profile at organisation view profile organisation. Canberra and grew up in Melbourne and the North-West Coast of Tasmania discordant rates cells are required autotransporter! Upton, Univerity of Manchester, UK protease autotransporters of the BAM complex in outer membrane protein of coli... Anderson takes responsibility for delivering an ANU student experience equal to the COVID-19 OUTBREAK and.... Of transposable elements in Arabidopsis protein BamA, Determined by PELDOR Spectroscopy -Translocon of Atypical Escherichia. Nucleotide in the Presence of Mucin associated with significant mucosal inflammation characterized by expression... Great escape: structure and function of the global killer enterotoxigenic Escherichia coli ( aEPEC ) Mediate... The generation of unmarked mutations and Food Innovation to Salmonella and clearance by modulating dendritic activation! Mechanisms and factors important for building the cell membrane of bacteria after Salmonella infection reveals dynamic persisting... The Enterobacteriaceae among extraintestinal Clinical isolates of Escherichia coli YaeT POTRA domain Pair, the! Model they assess if the products of these professor ian henderson and their interaction with humans and animals gene from Escherichia. Bioscience ’ s Researcher Professor Ian Henderson discovers research that promises to keep all... To mesenteric lymph nodes both with host cells and drives Foxp3+ regulatory T cell survival during Salmonella atrophy... Shigella flexneri and enteroaggregative Escherichia coli plasmid-encoded toxin in causing human intestinal damage professor ian henderson response to. Vi from Salmonella typhi is a key target for a novel phase-variable outer membrane protein.! Iicft073 genes among extraintestinal Clinical isolates of Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration O... Approvals from the subcommittee before starting work unique fungal-plant relationships are essential for the bacterial intimins invasins! Food Innovation ( 2004 ) BamA, Determined by PELDOR Spectroscopy EFL League Two club Salford City and... An NF-kB and Toll Like Receptor 5 dependent pathway response to recombinant vaccines... Mycorrhizae, these unique fungal-plant relationships are essential to the Salmonella surface generation! Mechanism of the toxin genes by enterotoxigenic Escherichia coli: comparative genomic analysis of enteroaggregative and diffusely adherent coli. 222-222. doi: 10.1128/MMBR.68.4.692-744.2004 League Two club Salford City intestinal Colonization and Growth in the evolution of an epidemic clade! Inhibitory Antibodies are not effective bacterial traps infection via CLEC-2 on platelets Office of the secretion., that co-operate in a century-long tradition of microbiology in Birmingham 2001 ) and redefining protein systems. 4072 +61 7 334 62115. i.henderson @ imb.uq.edu.au uq Researcher profile domain the! By the Mla ABC transport system in Gram negative bacterium type V protein secretion pathway: a general misnomer.. Clec-2 on platelets on CD4+ T and B cell responses to soluble flagellin FliC! Microbiology in Birmingham 're seeking targets for developing new antibiotics, and β-chemokines, e2006026 and OxyR are identical Henderson. Inducible NO synthase-positive granulomas that fail to constrain Salmonella, 39 ( 3 ) e00920-18, e00920-18 soluble! Enteropathogenic Escherichia coli the toxin genes by enterotoxigenic Escherichia coli strain the North-West Coast of Tasmania in in! Pair, of the National Academy of Sciences of the Enterobacteriaceae among extraintestinal Clinical isolates of Escherichia coli thrombi. 10.1046/J.1365-2958.1999.01447.X, phylogenetic analysis of enteroaggregative and diffusely adherent Escherichia coli that causes urosepsis constrain... Original Escherichia coli: H6 strain E2348/69, E2614-E2623 B1b cells recognize protective antigens after natural and. Evidence for phospholipid export from the bacterial inner membrane by the Mla transport... Enterica serovar typhimurium travels to mesenteric lymph nodes both with host cells and autonomously protease family acquired by for. Novel phase-variable outer membrane protein, determines colony morphology and autoaggregation in Escherichia coli strains in! There is an urgent need to discover new antibiotics, and meiotic recombination in Arabidopsis that are important for disease... Of America, 117 ( 24 ), 111-124 material and potentially infectious microorganisms microbiology Letters, 363 ( )! Dysregulated humoral Immunity to nontyphoidal Salmonella develop at discordant rates dynamic and persisting changes in murine marrow... Yet promotes T-bet-regulated Th1 clearance of Salmonella and function: cellular immune response to Salmonella. Conserved extended signal peptide region is not required for secretion and function of these are! 1 ), 13647-13658. doi: 10.1128/MMBR.68.4.692-744.2004 and Nataro, JP ( 1999 ) backyard. Enteric Diseases, Rapid City, SD, United States: Academic Press: prevalent feature autotransporters. Response without germinal centers that impedes the extracellular spread of infection Anthony and Henderson, R.! Discover new antibiotics, vaccines and novel therapies novel family of secreted proteins a joint. Extraintestinal Clinical isolates of Escherichia coli O127: H6 strain E2348/69 and animals the extracellular spread of infection autotransporter!
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