Increased levels of HbF in red blood cells have been demonstrated to improve symptomology and lower disease burden in patients with sickle cell disease and patients with beta-thalassemia.About Imara Imara Inc. is a clinical-stage biotechnology company dedicated to developing and commercializing novel therapeutics to treat patients suffering from rare inherited genetic disorders of hemoglobin. About IMR-687 IMR-687 is a highly selective and potent small molecule inhibitor of PDE9. Following the completion of 52 weeks of treatment in the trial, patients will be eligible to enroll in an open-label extension study.

For more information, please visit www.imaratx.com. Imara Roose Inc. is a 501(c)(3) nonprofit mentoring program for black and brown girls at Eleanor Roosevelt High School in Greenbelt, MD. La tua situazione sarà controllata dai nostri moderatori.

Intraday data delayed at least 15 minutes or per exchange requirements. BOSTON, Aug. 13, 2020 (GLOBE NEWSWIRE) -- Imara Inc. (NASDAQ:IMRA), a clinical-stage biopharmaceutical company dedicated to developing and commercializing novel therapeutics to treat patients suffering from rare inherited genetic disorders of hemoglobin, today announced dosing of the first patient in the company's Ardent Phase 2b clinical trial of IMR-687 for adult patients with sickle cell disease (SCD). IMR-687 is being designed to have a multimodal mechanism of action that acts on red blood cells, white blood cells, adhesion mediators and other cell types. The organization is driven by women of color—young professionals, undergrad and graduate students. La tua possibilità di commentare è stata sospesa per via di report negativi da parte di altri utenti.

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Committed to making a difference for patients, their families and the broader communities affected by sickle cell disease and beta-thalassemia. Sei sicuro di voler bloccare %USER_NAME%? Imara will host a conference call and live webcast today at 8:30 a.m. Sotto potete trovare informazioni sulle Azioni di Imara (IMRA). Imara is currently developing IMR-687, a highly selective, potent small molecule inhibitor of PDE9, to treat patients with sickle cell disease. For more information, please visit www.imaratx.com.Media Contact: Gina Nugent Ten Bridge Communications 617-460-3579 gina@tenbridgecommunications.comInvestor Contact: Michael Gray 617-835-4061 mgray@imaratx.com, BOSTON, Aug. 25, 2020 (GLOBE NEWSWIRE) -- Imara Inc. (Nasdaq: IMRA), a clinical-stage biopharmaceutical company dedicated to developing and commercializing novel therapeutics to treat patients suffering from rare inherited genetic disorders of hemoglobin, today announced that the European Commission granted Orphan Drug designation to IMR-687 for the treatment of patients with sickle cell disease (SCD). Imara, Inc. engages in the development and commercialization of novel therapeutics to treat patients suffering from hemoglobinopathies. Its product candidate, IMR …

In addition, the company has an ongoing open label extension (OLE) clinical trial, which allows patients from the Phase 2a clinical trial to continue into a long-term, four-year trial to evaluate safety and tolerability of IMR-687. We operate directly and through partners in 10 African countries, as well as an office in London. IMR-687 is being designed to have a multimodal mechanism of action that acts on red blood cells, white blood cells, adhesion mediators and other cell types. IMR-687 has previously been granted Orphan Drug, Fast Track and Rare Pediatric Disease designations from the U.S. Food and Drug Administration (FDA) for the treatment of patients with SCD. IMR-687 is being designed to have a multimodal mechanism of action that acts on red blood cells, white blood cells, adhesion mediators and other cell types. ET, BOSTON, Aug. 14, 2020 (GLOBE NEWSWIRE) -- Imara Inc. (NASDAQ:IMRA), a clinical-stage biopharmaceutical company dedicated to developing and commercializing novel therapeutics to treat patients suffering…. Patient randomization will be stratified by use of hydroxyurea (HU) as well as by region, and weight-based dosing will be employed to optimize drug exposure and tolerability. Privacy Policy The live webcast will be available under "Events and Presentations" in the Investors section of the Company's website at imaratx.com. Privacy Notice and About ImaraImara Inc. is a clinical-stage biotechnology company dedicated to developing and commercializing novel therapeutics to treat patients suffering from rare inherited genetic disorders of hemoglobin. Any forward-looking statements contained in this press release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. Media Contact:Gina NugentTen Bridge Communications617-460-3579[email protected], Investor Contact:Michael Gray617-835-4061[email protected], CONDENSED CONSOLIDATED BALANCE SHEET DATA. Media Contact: Gina Nugent Ten Bridge Communications 617-460-3579 [email protected], Investor Contact: Michael Gray 617-835-4061 [email protected]. In the higher dose 100/200 mg cohort, IMR-687 monotherapy showed a statistically significant (p = 0.022) increase in the number of F-cells, which are red blood cells containing fetal hemoglobin (HbF), as well as a dose-dependent increase in HbF levels in adult patients with SCD. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the impact of extraordinary external events, such as the risks and uncertainties resulting from the impact of the COVID-19 pandemic on the Company's business, operations, strategy, goals and anticipated milestones, including its ongoing and planned research activities and ability to conduct and readout data from its ongoing Phase 2a clinical trial of IMR-687 in sickle cell disease and its ability to enroll, dose and readout data from its open label extension clinical trial of IMR-687 in sickle cell disease and its Phase 2b clinical trials of IMR-687 in sickle cell disease and beta-thalassemia; the Company's ability to advance the development of IMR-687 under the timelines it projects in current and future clinical trials, demonstrate in any current and future clinical trials the requisite safety and efficacy of IMR-687, replicate scientific and non-clinical data in clinical trials, obtain and maintain necessary regulatory approvals, obtain, maintain and enforce necessary patent and other intellectual property protection, identify, enter into and maintain collaboration agreements with third parties, manage competition, manage expenses, raise the substantial additional capital needed to achieve its business objectives, attract and retain qualified personnel, and successfully execute on its business strategies; and other factors discussed in the "Risk Factors" section of the Company's most recent Quarterly Report on Form 10-Q, which is on file with the Securities and Exchange Commission and in other filings that the Company makes with the Securities and Exchange Commission in the future.

Log in to see them here or sign up to get started. Create a list of the investments you want to track. Lower levels of cGMP are often found in people with sickle cell disease and beta-thalassemia and are associated with impaired blood flow, increased inflammation, greater cell adhesion and reduced nitric oxide mediated vasodilation.Blocking PDE9 acts to increase cGMP levels, which are associated with reactivation of fetal hemoglobin, or HbF, a natural hemoglobin produced during fetal development. Boston, MA 02116

Imara Roose Inc. is a 501(c)(3) nonprofit mentoring program for black and brown girls at Eleanor Roosevelt High School in Greenbelt, MD. Imara Strengthens Board of Directors With Appointment of Edward R. Conner, M.D. A live webcast will be available under "Events and Presentations" in the Investors section of the company's website at imaratx.com. Increased levels of HbF in red blood cells have been demonstrated to improve symptomology and lower disease burden in patients with sickle cell disease and patients with beta-thalassemia.

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"As we head into the second half of 2020, we are encouraged by several advancements across our programs that bring us closer to providing oral treatment options to patients with rare blood disorders," said Rahul Ballal, Ph.D., President and Chief Executive Officer of Imara. Flexible Fuel Tank Market 2020 Global Industry Trends, Statistics, Competition Strategies, Revenue Analysis, Key Players, Regional Analysis by Forecast to 2026, New Stocks Added to Biotech / Coronavirus Stocks Directory this Week, Flexible Fuel Tank Market 2019 Global Overview, Latest Technologies, Business Strategy, Key Vendors, Segments, Demands, Growth Factors, Size, Share by Forecast to 2025. E: info@imaratx.com. We believe that this increased exposure could have a meaningful impact on the therapeutic effect of IMR-687 on patients enrolled in this trial.

Historical and current end-of-day data provided by FACTSET. ET to discuss its second quarter 2020 financial results and other business updates. Blocking PDE9 acts to increase cGMP levels, which are associated with reactivation of fetal hemoglobin, or HbF, a natural hemoglobin produced during fetal development. Visit a quote page and your recently viewed tickers will be displayed here. Poiché hai appena sbloccato questa persona, devi aspettare 48 ore prima di bloccarla nuovamente. "Specifically, the 300 mg and potentially 400 mg dose levels to be administered in the Ardent trial are designed to provide meaningful exposure to IMR-687 that could be up to two-fold higher than administered in our ongoing Phase 2a clinical trial. ET - Benign Hematology  * Dr. Ballal will participate in a virtual fireside chat at the Morgan Stanley 18th Annual Global Healthcare Conference on September 17, 2020 at 10:15 a.m. ET.A live webcast of the presentations will be available under "Events and Presentations" in the Investors section of the company's website at www.imaratx.com.About Imara Imara Inc. is a clinical-stage biotechnology company dedicated to developing and commercializing novel therapeutics to treat patients suffering from rare inherited genetic disorders of hemoglobin. By using this site, you agree to the Subscriber Agreement & Terms of Use CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS, (in thousands, except share and per share data) (Unaudited).

Ardent IMR-687 Phase 2b Clinical Trial Design. Grazie per aver commentato. IMR-687 is being designed to have a multimodal mechanism of action that acts on red blood cells, white blood cells, adhesion mediators and other cell types. (1)   Working capital is defined as current assets less current liabilities. The company was founded by James G. McArthur in 2016 and is headquartered in Cambridge, MA. Increased levels of HbF in RBCs have been demonstrated to improve symptomology and substantially lower disease burden in both patients with SCD and patients with beta-thalassemia.

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